| Pair Name | Gynostemma Extract, Fluorouracil | ||
| Phytochemical Name | Gynostemma Extract (PubChem CID: / ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Gynostemma Extract, Fluorouracil | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Phosphorylation | H2AX | hsa3014 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Up-regulation | Phosphorylation | TP53 | hsa7157 | |
| In Vitro Model | SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 |
| SW620 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0547 | |
| Caco-2 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0025 | |
| In Vivo Model | Three mice were used as normal control, all others were inoculated with 0.1 ml of CT-26 cells (1×10⁷ cells/ml) into the left oxter region and randomly divided into 6 groups with 6–8 animals in each group. | |||
| Result | Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation | |||
| No. | Title | Href |
|---|---|---|
| 1 | Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation. PLoS One. 2015 Sep 14;10(9):e0137888. doi: 10.1371/journal.pone.0137888. | Click |
